Reynolds American Inc. (RAI) Sr. Staff Scientist - Product Integrity Nonclinical Studies in Winston Salem, North Carolina
Sr. Staff Scientist - Product Integrity Nonclinical Studies
Date:Jun 6, 2019
Location:Winston Salem, NC, US
Reynolds American Incorporated is positively transforming the tobacco industry. We’re a family of companies that strives for success in everything we do. The future inspires us because our people are igniting the breakthroughs that are redefining the ways adult tobacco consumers enjoy tobacco in the 21st century.
When other companies talk about growth, they only talk about size. At RAI, we focus on the growth of our people. We take pride in each other’s growth and well-being throughout our careers. We invest in your career and total well-being because we know our companies succeed when our people thrive.
At the RAI companies you’ll have the opportunity to work on iconic brands and revolutionary products by collaborating with visionary, principled and passionate people every day.
This position is within Reynolds American Services Company—a subsidiary that provides support services, including compliance, HR, law, finance, information management, and more to all of the subsidiaries of RAI.
RAI Services Company (RAIS) is seeking a well-organized Senior Staff Scientist within vitrotoxicology expertise to support the assessment of tobacco products consistent with RAIS’ Growth, Innovation and Harm Reduction platforms. The Nonclinical Scientist (Senior Staff Scientist) is a member of a core group of scientists involved in developing and applying newin vitroapproaches for the assessment of products. The individual will drive an innovative program and establish effective collaborations with a multidisciplinary team of internal and external groups to meet business requirements.
The incumbent will usein vitromodels to assess changes in mammalian/human cells in response to tobacco or tobacco-related exposure. The incumbent will evaluate, develop and qualify/validate new alternative test methods, assays andin vitromodels through engagement with stakeholders and relevant Contract Research Organizations (CROs)/external groups. The individual must independently manage and execute multiple projects, and maintain routine interaction with stakeholders to ensure critical timelines are met.
In this position, the individual must be a subject matter expert, will provide study oversight and train study monitors in application of various methods. The individual will disseminate results through internal meetings, external presentations and publications.
Principal Duties and Responsibilities:
Identify, develop, validate and apply alternativein vitromethods and models to support product assessment and regulatory submissions
Work closely with internal clients to implement research and testing strategies
Serve as Study Monitor and/or provide support as a scientific expert for model development andin vitrotoxicology studies conducted through CROs and other institutions
Participate in the selection and qualification of applicable CROs
Manage the logistics of study initiation/conduct at CROs, including protocol development, budget management/tracking, ongoing oversight, troubleshooting, data interpretation/review and completion of final report
Conduct and/or oversee onsite monitoring visits and technical/compliance audits
Ensure GLP compliance in all applicable studies
Disseminate results through internal meetings, external presentations and publications.
Required Education and Experience:
PhD in Toxicology, Cellular Biology, Biological Sciences, Biochemistry or closely related discipline
Minimum of 2-5 years of relevant experience conductingin vitroresearch and molecular toxicological studies
Experience in alternativein vitromodel/assay development and method validation
Ability to conceive, plan and conduct strategic research objectives
Experience in oversight ofin vitrotoxicology studies
Knowledge of mechanisms of smoking/tobacco-related diseases
Demonstrated ability to work both independently and as part of a team
Ability to apply critical thinking and problem solving skills
Demonstrated ability to manage and execute multiple projects simultaneously
Demonstrated project management, computer and data analysis skills
Excellent interpersonal, written and oral communication skills
Ability to travel internationally
The ideal candidate will possess:
Experience with complex cell models including but not limited to organotypic and co-cultures, and physiologically-relevant methods
Experience with molecular biology assays and bioinformatics tools
Knowledge of and experience with development and application of adverse outcome pathways (AOPs)
Experience with nonclinical studies using tobacco smoke and/or inhalation toxicology experience
Experience within vivostudies and/orin vitro-in vivoconnections
Established publication record in peer-reviewed journals; including primary authorship
Training and experience in the conduct of nonclinical studies compliant with 21 CFR part 58 and part 11 GLP regulatory requirements
Competitive Annual Salary
Targeted Annual Bonus
Relocation assistance available for those who qualify.
Our company offers very competitive compensation and benefit plans, including:
401(k) plan that offers opportunity to save on pre- and post-tax basis up to 50 percent of eligible compensation. Company matches 100 percent of employee pre-tax/Roth (401k) contributions up to six percent
Comprehensive health- and welfare-benefits package
Eleven paid company holidays annually, plus a generous paid vacation plan based on length of service
Company-paid sick and personal days, funeral leave and jury duty leave
Confidential personal financial counseling service
On-site health clinics and fitness centers
A matching grants program that enables employees to direct and double their donations to qualifying charitable organizations of their choice
Health-care advocacy service
Volunteer service opportunities
Federal credit union membership through Allegacy Federal Credit Union
Extensive training opportunities
ABOUT OUR ORGANIZATION:
Reynolds American Inc. is an indirect, wholly owned subsidiary of British American Tobacco p.l.c., and the U.S. parent company of R. J. Reynolds Tobacco Company; Santa Fe Natural Tobacco Company, Inc.; American Snuff Company, LLC; Niconovum USA, Inc.; Niconovum AB; R. J. Reynolds Vapor Company; Lorillard Licensing Company, LLC; and Reynolds Brands, Inc..
Reynolds American Inc. and its affiliated companies is an Equal Opportunity / Affirmative Action Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Our organization offers a level of challenge, responsibility and creativity for motivated employees that stands apart from the crowd.
We are also committed to employing a diverse workforce and valuing different perspectives, experiences and talents to maximize the company's potential for successfully achieving its business objectives.
Onlyapplicants requiring reasonable accommodation for any part of the application and hiring process should contact us directly.
Nearest Major Market:Winston-Salem
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